DNA sequencing involves taking a DNA molecule and determining its specific sequence of nucleotides (bases). There are many different techniques for sequencing DNA.
Sequencing of genomes or exomes does not involve sequencing of individual chromosomes. Instead, DNA is typically randomly fragmented into many small pieces that are each sequenced individually. This generates many short DNA sequences that are then computationally reassembled to generate the complete genome or exome sequence. Advances in DNA sequencing technology have dramatically reduced the cost and time necessary to sequence entire exomes and genomes.Learn more about our lab’s sequencing process